منابع مشابه
Essential fatty acid metabolism and its modification in atopic eczema.
Research from the 1930s to the 1950s established that a deficit of n-6 essential fatty acids (EFAs) leads to an inflammatory skin condition in both animals and humans. In a common inherited skin condition, atopic dermatitis (eczema), there was evidence of low blood EFA concentrations and of a therapeutic response to exceptionally high doses of linoleic acid. More recently, it has been establish...
متن کاملMetabolism of Essential Fatty Acids
The fat deficiency disease in the rat (I), dog (2), and chick (3) is characterized in part by sharply increased concentrations of one or more trienoic acids in the tissues, as indicated by alkali isomerization analyses. Indeed, the increase in conjugatable triene in the mitochondrial fatty acids may be the first noticeable symptom of the onset of fat deficiency (4). The major triene component o...
متن کاملImpaired Fatty Acid Metabolism
To establish whether insulin resistance and/or postprandial fatty acid metabolism might contribute to familial combined hyperlipidemia (FCH) we have examined parameters of insulin resistance and lipid metabolism in six FCH kindreds. Probands and relatives (n = 56) were divided into three tertiles on the basis of fasting plasma triglycerides (TG). Individuals in the highest tertile (TG > 2.5 mM;...
متن کاملDiagnosing essential fatty acid deficiency.
authors and five references. They should not have tables or figures and should relate solely to an article published in Circulation within the preceding 12 weeks. Only some letters will be published. Authors of those selected for publication will receive prepublication proofs, and authors of the article cited in the letter will be invited to reply. Replies must be signed by all authors listed i...
متن کاملHydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism
Cancer cells exhibit characteristic changes in their metabolism with efforts being made to address them therapeutically. However, targeting metabolic enzymes as such is a major challenge due to their essentiality for normal proliferating cells. The most successful pharmaceutical targets are G protein-coupled receptors (GPCRs), with more than 40% of all currently available drugs acting through t...
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ژورنال
عنوان ژورنال: Proceedings of the Nutrition Society
سال: 1975
ISSN: 0029-6651,1475-2719
DOI: 10.1079/pns19750050